| Accession |
PRJCA023042 |
| Title |
Lung cancer scRNA-seq analyses uncover potential mechanisms causing different efficacy of target therapy and immunotherapy between EGFR 19del and L858R lung adenocarcinoma |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
EGFR 19del and L858R are two of the most prevalent mutations in LUAD, which are associated with different responses to targeted therapy and immunotherapy. However, tumor microenvironment and cellular heterogeneity related to these distinct efficacies among the EGFR-mutant subtypes in LUAD remains unclear. We plan to explore possible reasons for different responses between two mutation subtypes. |
| Sample scope |
Single cell |
| Release date |
2024-02-03 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2022YFF0705300
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
52272281
|
|
|
|
| Submitter |
Hao
Wang (1553082@tongji.edu.cn)
|
| Organization |
Shanghai Pulmonary Hospital |
| Submission date |
2024-01-22 |
