| 项目编号 |
PRJCA023079 |
| 项目标题 |
Inhibiting RNA m6A Causes an Interferon Response in Cancer and Sustain T cell Function to Improve Cancer Immunotherapy |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
N6-methyladenosine (m6A) is the most abundant mRNA modification catalyzed by METTL3. This study showed METTL3 inhibited activated interferon response genes including Isg15 and Oas2. METTL3 inhibiting augmented sensitivity to ICB therapy with anti-PD-1 in B16 melanoma mouse model and can also sustain T cell function. |
| 样品范围 |
Multispecies |
| 发布日期 |
2024-07-02 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| the National Key R&D Program of China
|
|
2019YFA0110200
|
|
| The National Natural Science Foundation of China
|
|
32225012
|
|
|
|
| 提交者 |
Jiekai
Chen (chen_jiekai@gibh.ac.cn)
|
| 提交单位 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| 提交日期 |
2024-01-23 |
