| Accession |
PRJCA023298 |
| Title |
Clinical and biomarker analyses of anti-PD-(L)1 based combined therapy as a later-line treatment for patients with MSS-colorectal cancer liver metastasis |
| Relevance |
Medical |
| Data types |
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
In this study, we conducted a retrospective trial to assess the potential of SAA as a predictive biomarker for clinical response and side effects in patients with MSS-CRLM undergoing treatment with ICIs based treatment. Furthermore, we employed RNA-seq and multiplex immunohistochemistry (mIHC) techniques to conduct immune infiltration and spatial analysis of the TME in MSS-CRLM. These findings shed light on the immunosuppressive role of SAA in the tumor response to ICIs, providing new clinical features and potential therapeutic targets for MSS-CRLM patients resistant to immunotherapy. |
| Sample scope |
Multiisolate |
| Release date |
2024-01-29 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| No funding support
|
|
|
|
|
|
| Submitter |
Weili
Zhang (zhangwl3@sysucc.org.cn)
|
| Organization |
Sun Yat-sen University Cancer Canter |
| Submission date |
2024-01-29 |
