| Accession |
PRJCA023404 |
| Title |
Multiomics depicting the immunometabolism landscape of steatotic livers undergoing bariatric surgery and diet intervention |
| Relevance |
Medical |
| Data types |
Spatial metabolomics
|
| Organisms |
Rodentia
|
| Description |
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease worldwide that encompasses a spectrum of steatosis, inflammation, and fibrosis. Evidence suggests that weight loss approaches such as dietary intervention (DI) and bariatric surgery (BS) can lead to remission of hepatic steatosis and inflammation. However, it remains unclear about the effects of weight loss on the hepatic immune mechanisms in MASLD. Therefore, this study aims to elucidate the intricate immunometabolic landscape of steatotic livers following DI and BS by employinh the sleeve gastrectomy (a typical BS procedure) and comparable food intake after sham surgery in a rat model of MASLD. Single-cell (sc) and single-nuclei (sn) transcriptome analysis together with spatial metabolomics and immunohistochemistry were utilized to depict immunometabolic landscape, while circulating markers were assessed in serum. Furthermore, artificial intelligence (AI)-based image analysis was introduced to characterize the distribution of hepatocytes, myeloid cells and lymphocytes. |
| Sample scope |
Monoisolate |
| Release date |
2024-05-30 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Multiomics analyses decipher intricate changes in the cellular and metabolic landscape of steatotic livers upon dietary restriction and sleeve gastrectomy
|
bioRxiv
|
10.1101/2024.04.10.588826
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82300730
|
|
|
|
| Submitter |
Hanyang
Liu (brandenliu@live.com)
|
| Organization |
The Affiliated Changzhou Second People's Hospital of Nanjing Medical University |
| Submission date |
2024-02-02 |
