| 项目编号 |
PRJCA023625 |
| 项目标题 |
Activation of ERβ hijacks the splicing machinery to trigger R-loop formation in triple-negative breast cancer |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
While accumulating evidence has proved the presence of ERβ (estrogen receptor β) expression in TNBC (triple-negative breast cancer), the functional roles ERβ in TNBC have been controversial. Our study has demonstrated that the activation of ERβ hijacks the splicing machinery to modulate intron retention of 5-oxoprolinase (OPLAH), encoding a critical enzyme OPLAH involved in glutathione metabolism and oxidative stress. Altered splicing of OPLAH results in R-loop formation and DNA damage in TNBC cells. The identification of this molecular mechanism offers broad therapeutic avenues for future development of ERβ inhibitor and optimized combination therapies as treatment of TNBCs in the clinical setting. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-02-19 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38513102
|
Activation of ERβ hijacks the splicing machinery to trigger R-loop formation in triple-negative breast cancer
|
Proceedings of the National Academy of Sciences of the United States of America
|
10.1073/pnas.2306814121
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82325039
|
|
|
|
| 提交者 |
Shengtao
Zhou (taotaovip2005@163.com)
|
| 提交单位 |
West China Second University Hospital |
| 提交日期 |
2024-02-18 |
