| Accession |
PRJCA023891 |
| Title |
A pathological joint-liver axis mediated by matrikine-activated CD4+ T cells |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
CyTOF
|
| Organisms |
Mus musculus
|
| Description |
The knee joint has long been considered a closed system. The pathologic effects of joint disease on distant organs have not been studied. Here, our clinical data showed that post-traumatic joint damage combined with joint bleeding (hemarthrosis) caused worse liver function compared to healthy control. Using a mouse model, hemarthrosis induces both cartilage degeneration and distant liver damage. Next, we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4+ T cells in peripheral blood and spleen. Deletion of CD4+ T cells reversed hemarthrosis-induced liver damage. Degeneration of cartilage matrix induced by hemarthrosis upregulates serological type II collagen (COLII), which activates CD4+ T cells. Systemic application of a COLII antibody blocks this activation. Furthermore, bulk RNAseq and single cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood treatment. Intra-articular application of Akt activator blocks cartilage degeneration and thus protects against liver injury in mouse and pig models. Taken together, our study revealed a pathological joint-liver axis mediated by matrikine-activated CD4+ T cells, which updates the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related diseases. |
| Sample scope |
Monoisolate |
| Release date |
2024-05-30 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38714712
|
A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells
|
Signal Transduction and Targeted Therapy
|
10.1038/s41392-024-01819-y
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Science Fund for Creative Research Groups
|
T2121004
|
|
|
|
| Submitter |
Hongwei
Ouyang (hwoy@zju.edu.cn)
|
| Organization |
Zhejiang University |
| Submission date |
2024-02-27 |
