| Accession |
PRJCA023917 |
| Title |
Unveiling the Immune Cell Lineage Mechanisms in COVID-19-Induced Bronchoalveolar Dysfunction |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
This study utilized the 10x Genomics single-cell RNA sequencing method to analyze changes in immune cell lineages in the bronchoalveolar lavage fluid (BALF) of three severe COVID-19 patients. The research revealed a significant increase in the activation of specific immune cell lineages in COVID-19 patients compared to healthy controls, notably monocytes/neutrophils and macrophages. Furthermore, our study found that the highly activated monocytes and neutrophils, rather than macrophages, were the source of the exacerbated immune response characterized by increased IL1β. |
| Sample scope |
Single cell |
| Release date |
2024-03-10 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients
|
Protein & Cell
|
10.1007/s13238-020-00752-4
|
2020
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key R&D Program of China
|
2019YFA0110200
|
|
|
|
| Submitter |
Jiekai
Chen (chen_jiekai@gibh.ac.cn)
|
| Organization |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| Submission date |
2024-02-28 |
