| 项目编号 |
PRJCA023957 |
| 项目标题 |
Plasma and Tissue Metabolomics in Renal Cancer Patients with Von Hippel-Lindau Syndrome |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This project delves into the metabolic alterations associated with renal cell carcinoma (RCC) in patients suffering from Von Hippel-Lindau (VHL) Syndrome, an autosomal dominant cancer syndrome marked by a high mortality rate due to RCC. Our objective is to harness metabolomics to pinpoint specific and sensitive metabolite markers in this unique patient group, thereby aiding in the broader screening, early diagnosis, intervention, and prognosis of VHL-RCC. Analyzing plasma from 61 VHL-RCC patients and 31 healthy controls, along with 19 paired RCC tumor and adjacent non-malignant tissue samples, we employed Liquid Chromatography-Mass Spectrometry for metabolomics. This approach led to the identification of critical metabolite markers, uncovering metabolic insights for the therapeutic development of this disease. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-06-11 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Metabolomic Landscape of Renal Cell Carcinoma in Von Hippel-Lindau Syndrome in a Chinese cohort
|
iScience
|
10.1016/j.isci.2024.110357
|
2024
|
|
|
Suppression of ASNS expression by VHL-mediated ubiquitination hinders the progression of renal cell carcinoma through enhancing JUP expression and inhibiting …
|
International Journal of Biological Sciences
|
10.7150/ijbs.129332
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82141103
|
|
|
|
| 提交者 |
Kan
Gong (gongkan_pku@126.com)
|
| 提交单位 |
Peking University First Hospital |
| 提交日期 |
2024-02-29 |
