| Description |
This study outlines the establishment and characterization of a common HLA-typed induced pluripotent stem cell (iPSC) resource bank, aimed at advancing regenerative medicine and immunology. By reprogramming somatic cells from diverse donors, we created iPSC lines representing a broad spectrum of HLA types. Rigorous assessments confirmed their HLA typing, pluripotency, differentiation capability, and genomic stability. This resource bank is poised to enhance personalized and universal cell therapy applications by reducing immune rejection risks. It also offers a unique platform for exploring HLA's role in disease modeling, drug testing, and immune response studies, potentially accelerating the adoption of iPSC-based therapies and deepening our understanding of immune mechanisms. Future efforts will expand the bank's HLA diversity and explore its biomedical applications. |
