| Accession |
PRJCA024065 |
| Title |
Vitronectin enhances hematopoiesis of human pluripotent stem cells |
| Relevance |
Medical |
| Data types |
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
VTN and MTG are routinely used for hPSC culture. To investigate their roles in hematopoiesis, we compared the molecular changes between VTN and MTG.A transcriptome analysis was applied after 6 days of hematopoietic differentiation from H1-ESC. The genes in VTN-cultured cells were strongly enriched for the GO terms related to hematopoietic differentiation, including SPN, GATA2, SPI1, GFI1B and KLF1, and were significantly upregulated. Downregulated genes in VTN-cultured cells were related to neurogenesis and were mainly enriched for axon development. |
| Sample scope |
Monoisolate |
| Release date |
2024-03-10 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Vitronectin-activated αvβ3 and αvβ5 integrin signalling specifies haematopoietic fate in human pluripotent stem cells
|
Cell Proliferation
|
10.1111/cpr.13012
|
2021
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2019YFA0110200
|
|
|
|
| Submitter |
Jiekai
Chen (chen_jiekai@gibh.ac.cn)
|
| Organization |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| Submission date |
2024-03-05 |
