| 项目编号 |
PRJCA024187 |
| 项目标题 |
Heterogeneity and Plasticity of Macrophages in Liver Metastasis |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Liver metastasis, an aggressive form of cancer progression with disappointing prognosis outcome, is enriched with immune-suppressive myeloid cells that induce T cell anergy and results in the resistance to immunotherapies. Unlike the liver metastasis-associated macrophages, the resident macrophages in healthy liver, also called Kupffer cells, line sinusoidal vessels and are in prime position to clear unfit red blood cells. This project investigated the heterogeneity and plasticity of macrophages from different origins in liver metastasis. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-10-05 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39472435
|
Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells
|
Nature Communications
|
10.1038/s41467-024-53659-7
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82173278
|
|
|
|
| 提交者 |
Lin
Tian (tianlin@sysucc.org.cn)
|
| 提交单位 |
Sun Yat-sen University Cancer Center |
| 提交日期 |
2024-03-10 |
