| 项目编号 | PRJCA024217 | ||||||||||||||||
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| 项目标题 | Whole-genome sequencing, PacBio long-read sequencing and single-cell RNA-seq of precancerous colorectal lesions in mouse models | ||||||||||||||||
| 涉及领域 | Evolution | ||||||||||||||||
| 数据类型 |
Whole genome sequencing
Genome sequencing Single cell sequencing PacBio Sequel IIe |
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| 物种名称 | Mus musculus | ||||||||||||||||
| 描述信息 | To elucidate the somatic lineages and evolutionary dynamics in preneoplastic lesions, we established a transgenic mouse line carrying the lineage tracing barcode and used it to generate lineage traced neoplastic lesions using two mouse models (an azoxymethane (AOM) and dextran sodium sulfate (DSS) mouse model and an ApcMin/+ mouse model) of colorectal tumorigenesis. Through integrated analyses of single cell phylogenies (n=105 samples), whole-genome sequencing (n=31 mouse samples) and single-cell RNA sequencing (n=9 mouse samples), we have investigated the trajectory of intestinal tumorigenesis observed in both mouse models. | ||||||||||||||||
| 样品范围 | Monoisolate | ||||||||||||||||
| 发布日期 | 2024-07-31 | ||||||||||||||||
| 实验材料提供者 | Zheng Hu | ||||||||||||||||
| 项目资金来源 |
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| 提交者 | Zheng Hu (zheng.hu@siat.ac.cn) | ||||||||||||||||
| 提交单位 | Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences | ||||||||||||||||
| 提交日期 | 2024-03-08 |