| 项目编号 | PRJCA024406 | ||||||||
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| 项目标题 | Molecular mechanisms of Tbx2 regulating inner hair cell development and cell fate determination | ||||||||
| 涉及领域 | Evolution | ||||||||
| 数据类型 |
Epigenomics
Transcriptome or Gene expression Single cell sequencing |
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| 物种名称 |
Mus musculus
Xenopus laevis Gallus gallus |
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| 描述信息 | More than 1.5 billion people in the world suffer from different degrees of hearing loss, which seriously affects people's health. Dysfunction or death of cochlear hair cells is the most common cause of hearing impairment, and the molecular mechanisms of hair cell development, cell fate determination and regeneration arethe core scientific questions in the field of inner ear research. Recently, itfound that Tbx2 is a key regulator of cochlear inner hair cell development and fate determination, but the specific mechanism for how Tbx2 regulates inner hair cell development and fate determination is still unclear, Our previous research revealed the mechanism of transcription factors Six1/Eya1/Brg1 in regulation of inner ear development and the correlation of Six1/Eya1/Brg1 regulated gene network to the function of Tbx2, which will provide insights into molecular mechanism of Tbx2. This study intends to use a variety of genetic, transcriptomic, genomic and proteomic approaches to study the spatiotemporal expression characteristics of Tbx2 in inner ear and analyze the mechanism how Tbx2 interacts with its key cofactor, regulates the activity of cis-regulatory elements (enhancer), affects the development of cochlea hair cell and determines the cell fate. This project will provide a theoretical foundation for cochlear hair cell transdifferentiation, regeneration and hearing restoration therapy. | ||||||||
| 样品范围 | Multispecies | ||||||||
| 发布日期 | 2024-12-02 | ||||||||
| 项目资金来源 |
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| 提交者 | Yafan Wang (wyf15225013203@163.com) | ||||||||
| 提交单位 | University of Chinese Academy of Sciences | ||||||||
| 提交日期 | 2024-03-18 |