| 项目编号 |
PRJCA024569 |
| 项目标题 |
SF3B1 mutation in uveal melanoma |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
SF3B1 is the most frequently mutated splicing factor in human cancer. SF3B1 mutations lead to cryptic 3' splice site selection, and the splicing pattern demonstrates a clear hotspot and tumor lineage specificity. Here, we introduced the top two commonly mutated SF3B1 hotspots, K700E and R625, into human melanocytes, melanoma cell lines, and hematological cancer cell lines to compare the diversity of mis-splicing. Furthermore, we aimed to clarify the key functions induced by the SF3B1 R625H mutation, which drives oncogenesis in melanoma. |
| 样品范围 |
Synthetic |
| 发布日期 |
2025-10-21 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Chinese Academy of Sciences (CAS)
|
|
NA
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32170565
|
|
| National Key R&D Program of China
|
|
2022YFC2704202
|
|
|
|
| 提交者 |
Zhaoqi
Liu (liuzq@big.ac.cn)
|
| 提交单位 |
Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation |
| 提交日期 |
2024-03-22 |
