| 项目编号 |
PRJCA024580 |
| 项目标题 |
Epigenetic study of lung adenocarcinoma |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Lung adenocarcinoma, a prevalent sub type of lung cancer, serves as the focal point of our project. We meticulously collected specimens across various stages of lung adenocarcinoma development alongside control samples from conditions such as pneumonia and pulmonary fibrosis . Utilizing advanced genomic techniques, including Whole Genome Bisulfite Sequencing , Assay for Transposase-Accessible Chromatin sequencing , and RNA sequencing, we conducted comprehensive analyses on these specimens. Our approach enabled the creation of detailed epigenetic landscapes of lung adenocarcinoma at differing stages of its evolution. By integrating this with stage-specific expression profiles, we delved into the epigenetic underpinnings that drive the progression of lung adenocarcinoma, aiming to uncover novel insights into its pathogenesis. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-04-03 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41019373
|
Epigenetic-mediated positive feedback loop facilitates the progression of lung adenocarcinoma
|
iScience
|
10.1016/j.isci.2025.113339
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2022YFA1105200
|
|
|
|
| 提交者 |
Deqiang
Sun (sund@gzhmu.edu.cn)
|
| 提交单位 |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2024-03-22 |
