| 项目编号 |
PRJCA024705 |
| 项目标题 |
Tyrosine phosphorylation of band 3 impairs the storage quality of SRBCs in Tibet HAPC population |
| 涉及领域 |
Medical |
| 数据类型 |
Metabolome;Proteome; Lipidome;Gut flora
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
After human bodies become accustomed to the hypoxic conditions of high altitudes and then return to the plain, there is a compensatory adjustment process called "de-adaptation" where the body gradually reverses the physiological changes made to adapt to the hypoxic environment. This process often accompanies varying degrees of discomfort and alterations in physiological markers, significantly affecting the health of individuals who frequently traverse between high and low altitudes. This study focuses on examining the multi-omics profile (metabolomics, proteomics, etc.) and physiological function changes among highland residents, particularly those with high altitude polycythemia, at different stages of the de-adaptation process. By analyzing the correlation between red blood cell (RBC) metabolic reprogramming, oxygen transport function, and the development of de-adaptation syndromes, we aim to clarify the patterns of RBC metabolic reprogramming during de-adaptation and identify potential therapeutic targets for these syndromes. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-02-28 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Exposure to high altitude leads to disturbances in host metabolic homeostasis: study of the effects of hypoxia-reoxygenation and the associations between the …
|
mSystems
|
10.1128/msystems.01347-24
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
the central government guides the local science and technology development fund project
|
XZ202201YD0013C
|
|
|
|
| 提交者 |
Zeng
He (henkally@163.com)
|
| 提交单位 |
Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region |
| 提交日期 |
2024-03-27 |
