| Accession |
PRJCA024831 |
| Title |
SPP1+ TAM regulates the metastatic colonization of CXCR4+ metastasis-associated tumor cells by remodeling the lymph node microenvironment. |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Lymph node metastasis, the first stop for distant metastasis, is a primary factor contributing to mortality in patients with oral squamous cell carcinoma (OSCC). However, the underlying mechanisms of lymph node metastasis in OSCC are yet to be fully elucidated. Here, we analyzed the transcriptomes of 56,383 single cells derived from paired tissues of six OSCC patients. We found that CXCR4+ epithelial cells, identified as highly malignant disseminated tumor cells (DTCs), exhibited a propensity for lymph node metastasis. Importantly, we discovered a distinct subset of tumor-associated macrophages (TAMs) characterized by exclusive expression of phosphoprotein 1 (SPP1). These TAMs may remodel the metastatic lymph node microenvironment by potentially activating fibroblasts and promoting T cell exhaustion through SPP1-CD44 and CD155-CD226 ligand-receptor interactions, thereby facilitating colonization and proliferation of disseminated tumor cells. Our research advanced the mechanistic understanding of metastatic tumor microenvironment (TME) and provided a foundation for the development of personalized treatments for OSCC patients with metastasis. |
| Sample scope |
Single cell |
| Release date |
2024-06-06 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 39236316
|
SPP1+ TAM Regulates the Metastatic Colonization of CXCR4+ Metastasis‐Associated Tumor Cells by Remodeling the Lymph Node Microenvironment
|
Advanced Science
|
10.1002/advs.202400524
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| This study was supported by National Key R&D Programmes (NKPs) of China
|
|
2022YFC3601800
|
|
| The Natural Science Foundation of China General Program
|
|
82073020
|
|
| Hunan Natural Science Foundation for Distinguished Young Scholars
|
|
2021JJ10073
|
|
|
|
| Submitter |
Mingzhu
Yin (yinmingzhu2008@126.com)
|
| Organization |
Chongqing University Three Gorges Hospital |
| Submission date |
2024-03-31 |
