| 项目编号 |
PRJCA024831 |
| 项目标题 |
SPP1+ TAM regulates the metastatic colonization of CXCR4+ metastasis-associated tumor cells by remodeling the lymph node microenvironment. |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Lymph node metastasis, the first stop for distant metastasis, is a primary factor contributing to mortality in patients with oral squamous cell carcinoma (OSCC). However, the underlying mechanisms of lymph node metastasis in OSCC are yet to be fully elucidated. Here, we analyzed the transcriptomes of 56,383 single cells derived from paired tissues of six OSCC patients. We found that CXCR4+ epithelial cells, identified as highly malignant disseminated tumor cells (DTCs), exhibited a propensity for lymph node metastasis. Importantly, we discovered a distinct subset of tumor-associated macrophages (TAMs) characterized by exclusive expression of phosphoprotein 1 (SPP1). These TAMs may remodel the metastatic lymph node microenvironment by potentially activating fibroblasts and promoting T cell exhaustion through SPP1-CD44 and CD155-CD226 ligand-receptor interactions, thereby facilitating colonization and proliferation of disseminated tumor cells. Our research advanced the mechanistic understanding of metastatic tumor microenvironment (TME) and provided a foundation for the development of personalized treatments for OSCC patients with metastasis. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-06-06 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39236316
|
SPP1+ TAM Regulates the Metastatic Colonization of CXCR4+ Metastasis‐Associated Tumor Cells by Remodeling the Lymph Node Microenvironment
|
Advanced Science
|
10.1002/advs.202400524
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| This study was supported by National Key R&D Programmes (NKPs) of China
|
|
2022YFC3601800
|
|
| The Natural Science Foundation of China General Program
|
|
82073020
|
|
| Hunan Natural Science Foundation for Distinguished Young Scholars
|
|
2021JJ10073
|
|
|
|
| 提交者 |
Mingzhu
Yin (yinmingzhu2008@126.com)
|
| 提交单位 |
Chongqing University Three Gorges Hospital |
| 提交日期 |
2024-03-31 |
