| Accession |
PRJCA024838 |
| Title |
Biological effects of extracellular vesicles of Lactobacillus crispatus FY121 on HPV |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Our study focused on extracellular vesicles of Lactobacillus crispatus FY121 (LcEVs), a common probiotic in the female vagina. These vesicles were found to reduce the expression of the human papillomavirus E6 and E7 genes and suppress the malignant phenotype of cervical cancer cells. In addition, to further investigate the mechanism, we used transcriptomic and proteomic analyses to explore the mechanism of action of LcEVs. |
| Sample scope |
Monoisolate |
| Release date |
2024-04-04 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81301703
|
|
| Heilongjiang Provincial Natural Science Foundation
|
|
LH2021H059
|
|
| Heilongjiang provincial research institute scientific research expenses project
|
|
CZKYF2022-1-C033
|
|
|
|
| Submitter |
Yong
Fang (yong.fang@ems.hrbmu.edu.cn)
|
| Organization |
Harbin Medical University |
| Submission date |
2024-04-01 |
