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Accession PRJCA024937
Title Multiomics Signatures Reveal Genomic and Functional Heterogeneity of Cutibacterium acnes in Normal and Diseased Skin
Relevance Medical
Data types Metabolome
Organisms Cutibacterium acnes
Description Cutibacterium acnes (C. acnes) is the most abundant bacteria of normal human skin since adolescence, participating in both skin homeostasis and diseases. Here, we revealed individual and niche heterogeneity of C. acnes by analyzing single-strain genomes. Skin disease (atopic dermatitis and acne) and body site shaped the genomic differences of C. acnes, contributed by horizontal gene transfer and selection pressure. Matched genome, transcriptome, and metabolome analysis at the single-bacteria level unveiled the functional characteristics of C. acnes.
Sample scope Multiisolate
Release date 2024-05-21
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 82330098
National Natural Science Foundation of China (NSFC) 82273531
National Natural Science Foundation of China (NSFC) 82073446
National Natural Science Foundation of China (NSFC) 82373489
National Natural Science Foundation of China (NSFC) 82003349
National Natural Science Foundation of China (NSFC) 82003357
National Natural Science Foundation of China (NSFC) 81972939
National Natural Science Foundation of China (NSFC) 62127810
Key Project of the Innovation Program of Shanghai Municipal Education Commission 2021-01-07-00-07-E00078
Clinical Research Plan of Shanghai Shenkang Hospital Development Center SHDC22022302
Shanghai Municipal Commission of Health and Family Planning 2023ZZ02018
Shanghai Municipal Key Clinical Specialty No-shslczdzk01002
National Key R&D Program of China 2022YFC3601800
Research Grants Council of the Hong Kong Special Administrative Region, China CityU11217221
Research Grants Council of the Hong Kong Special Administrative Region, China CityU11219419
Research Grants Council of the Hong Kong Special Administrative Region, China CityU11213720
Submitter TIANZE YU (tzyu22@m.fudan.edu.cn)
Organization Huashan Hospital Fudan University
Submission date 2024-04-03

Project Data

Resource name Description