| Accession |
PRJCA025074 |
| Title |
Effect of exercise at different time on rhythmic gene expression of bone tissue in male mice |
| Relevance |
Medical |
| Data types |
Raw sequence reads
|
| Organisms |
Mus musculus
|
| Description |
The timing of exercise is suggested to be one of the significant variables affecting physiological outcomes from exercise. The effects of exercise could differ based on the time of day, highlighting the need to account for this factor in the design of exercise interventions. The aim of this study was to elucidate the effects of exercise timing on development and rhythmic gene expression of bone tissue. We performed RNA sequencing on cartilaginous osteogenesis tissue of male mice following exercise or sham treatment at the rest phase (Zeitgeber time (ZT) 1, ZT5,) or the active phase (ZT13, ZT17, ZT21). Our results indicate that exercise in the early phase (ZT13) enhances the expression of genes associated with bone growth and induces daily oscillation of genes related to bone development and carbohydrate metabolism. Notably, exercising during the early active phase preserves the rhythmic expression patterns observed in sedentary individuals, whereas exercising during the rest phase disrupts these patterns. |
| Sample scope |
Monoisolate |
| Release date |
2024-04-26 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82030070
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31725011
|
|
| National Key Research and Development Program of China
|
|
2021YFC2400404
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82100960
|
|
|
|
| Submitter |
Shaoling
Yu (ysl_734286@163.com)
|
| Organization |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| Submission date |
2024-04-08 |
