| 项目编号 |
PRJCA025389 |
| 项目标题 |
UCASpatial Reconstructs Ultra-resolution Cellular Landscape in Spatial Transcriptomics to Reveal Multicellular Spatiotemporal Dynamics |
| 涉及领域 |
Spatial transcriptomics |
| 数据类型 |
Transcriptome or Gene expression
Single cell sequencing
|
| 物种名称 |
|
| 描述信息 |
Here, we present UCASpatial, an ultra-resolution cellular spectrum decomposition algorithm in spatial transcriptomics based on an entropy-weighted regression model for uncovering spatiotemporal transition and multicellular communities among cell subpopulations. UCASpatial demonstrates high sensitivity and accuracy in discriminating cell subpopulations with low proportion and subtle transcriptomic differences in ST, enabling precise resolution of cellular spectrum unbiasedly. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2026-01-29 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
32121001
|
|
| Strategic Priority Research Program of the Chinese Academy of Science
|
|
XDB0570101
|
|
| Beijing Natural Science Foundation
|
|
Z200023
|
|
|
|
| 提交者 |
Dali
Han (handl@big.ac.cn)
|
| 提交单位 |
Beijing Institute of Genomics, Chinese Academy of Sciences |
| 提交日期 |
2024-04-16 |
