| 项目编号 |
PRJCA025411 |
| 项目标题 |
Nucleoporin complex NPP-14/24 shape perinuclear germ granule architecture and coordinate piRNA silencing |
| 涉及领域 |
Model organism |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Caenorhabditis elegans
|
| 描述信息 |
Germ granules are RNA-rich biomolecular condensates containing factors for the posttranscriptional regulation of gene expression and the development of germ cells. In C. elegans, germ granules are associated with nuclear pore clusters. Previous studies have shown that assembly of P granules in the perinuclear region is critical for the fidelity of piRNA-mediated gene silencing. However, the mechanism by which germ granules associate with the nucleus and the functional relevance of such an association remain unknown. We uncovered the function of the NPP-14/24 complex in spatially organizing perinuclear germ granules and shed light on how organized germ granules function in fine-tuning the piRNA-based transcriptome surveillance and the inheritance of gene silencing. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-04-14 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40341687
|
Nucleoporins shape germ granule architecture and balance small RNA silencing pathways
|
Nature Communications
|
10.1038/s41467-025-59526-3
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
31922019
|
|
|
|
| 提交者 |
Donglei
Zhang (zhang_donglei@hust.edu.cn)
|
| 提交单位 |
Huazhong University of Science and Technology |
| 提交日期 |
2024-04-19 |
