项目编号

PRJCA025534

项目标题

Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates

涉及领域

Evolution

数据类型

Transcriptome or Gene expression
Single cell sequencing

物种名称

Branchiostoma floridae

描述信息

In this study, cells in the digestive tract of a cephalochordate, Brachiostoma floridae, were profiled using bulk-tissue and single-cell RNA-sequencing. Furthermore, Pdx, Ilp1, Ilp2, and Ilpr knockout amphioxus lines were investigated to study midgut development and Ilp function in detail.

样品范围

Monoisolate

发布日期

2024-12-10

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
39705360	Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates	Science Advances	10.1126/sciadv.adq0702	2024
41423499	volutionary dynamics of FoxQ2 transcription factors across metazoans reveals three ancient paralogs	Communications Biology	10.1038/s42003-025-09368-y	2025

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
National Natural Science Foundation of China (NSFC)		32100335
National Natural Science Foundation of China (NSFC)		32070458
National Natural Science Foundation of China (NSFC)		32061160471
National Natural Science Foundation of China (NSFC)		32070815
National Natural Science Foundation of China (NSFC)		32270439
National Natural Science Foundation of China (NSFC)		82050002
China Postdoctoral Science Foundation (CPSF)		273565
Bingzhi Postdoctoral Support Program		00000001

提交者

Xuming Zhou (zhouxuming@ioz.ac.cn)

提交单位

Institute of Zoology, Chinese Academy of Sciences

提交日期

2024-04-22

项目包含数据信息

资源名称	描述
BioSample (94) show	-
SAMC3554864	Pdx control, hindgut, sample 2, seq round 1, scRNA-seq
SAMC3554863	Pdx control, midgut, sample 2, seq round 1, scRNA-seq
SAMC3554862	Pdx mutant, midgut, sample 2, seq round 1, scRNA-seq
SAMC3554861	Pdx mutant, hindgut, sample 2, seq round 1, scRNA-seq
SAMC3554860	Pdx control, hindgut, sample 1, seq round 2, scRNA-seq
SAMC3554859	Pdx control, hindgut, sample 1, seq round 1, scRNA-seq
SAMC3554858	Pdx control, hepatic, sample 2, seq round 1, scRNA-seq
SAMC3554857	Pdx mutant, hepatic, sample 2, seq round 1, scRNA-seq
SAMC3554856	Pdx control, hepatic, sample 1, seq round 1, scRNA-seq
SAMC3554855	Pdx mutant, hindgut, sample 1, seq round 1, scRNA-seq
SAMC3554854	Pdx mutant, hepatic, sample 1, seq round 2, scRNA-seq
SAMC3554853	Pdx mutant, hepatic, sample 1, seq round 1, scRNA-seq
SAMC3554852	Pdx mutant, midgut, sample 1, seq round 1, scRNA-seq
SAMC3554851	Pdx control, midgut, sample 1, seq round 2, scRNA-seq
SAMC3554850	Pdx control, midgut, sample 1, seq round 1, scRNA-seq
SAMC3554849	Wildtype, adult testis, sample 3, RNA-seq
SAMC3554848	Wildtype, adult testis, sample 2, RNA-seq
SAMC3554847	Wildtype, adult testis, sample 1, RNA-seq
SAMC3554846	Wildtype, adult tentacles, sample 2, RNA-seq
SAMC3554845	Wildtype, adult tentacles, sample 1, RNA-seq
SAMC3554844	Wildtype, adult skin, sample 3, RNA-seq
SAMC3554843	Wildtype, adult skin, sample 2, RNA-seq
SAMC3554842	Wildtype, adult skin, sample 1, RNA-seq
SAMC3554841	Wildtype, adult rostrum, sample 4, RNA-seq
SAMC3554840	Wildtype, adult rostrum, sample 3, RNA-seq
SAMC3554839	Wildtype, adult rostrum, sample 2, RNA-seq
SAMC3554838	Wildtype, adult rostrum, sample 1, RNA-seq
SAMC3554837	Wildtype, adult ovary, sample 1, RNA-seq
SAMC3554836	Wildtype, adult notochord, sample 1, RNA-seq
SAMC3554835	Wildtype, adult neural tube, sample 3, RNA-seq
SAMC3554834	Wildtype, adult neural tube, sample 2, RNA-seq
SAMC3554833	Wildtype, adult neural tube, sample 1, RNA-seq
SAMC3554832	Wildtype, adult muscle, sample 2, RNA-seq
SAMC3554831	Wildtype, adult muscle, sample 1, RNA-seq
SAMC3554830	Wildtype, adult ACV2 (hindbrain), sample 3, RNA-seq
SAMC3554829	Wildtype, adult ACV2 (hindbrain), sample 2, RNA-seq
SAMC3554828	Wildtype, adult ACV2 (hindbrain), sample 1, RNA-seq
SAMC3554827	Wildtype, adult metapleural folds, sample 3, RNA-seq
SAMC3554826	Wildtype, adult metapleural folds, sample 2, RNA-seq
SAMC3554825	Wildtype, adult metapleural folds, sample 1, RNA-seq
SAMC3554824	Wildtype, adult ACV3 (hindbrain), sample 2, RNA-seq
SAMC3554823	Wildtype, adult ACV3 (hindbrain), sample 1, RNA-seq
SAMC3554822	Wildtype, adult hindgut, sample 3, RNA-seq
SAMC3554821	Wildtype, adult hindgut, sample 2, RNA-seq
SAMC3554820	Wildtype, adult hindgut, sample 1, RNA-seq
SAMC3554819	Wildtype, adult hepatic diverticulum, sample 3, RNA-seq
SAMC3554818	Wildtype, adult hepatic diverticulum, sample 2, RNA-seq
SAMC3554817	Wildtype, adult hepatic diverticulum, sample 1, RNA-seq
SAMC3554816	Wildtype, adult male Hatschek's pit, sample 3, RNA-seq
SAMC3554815	Wildtype, adult male Hatschek's pit, sample 2, RNA-seq
SAMC3554814	Wildtype, adult male Hatschek's pit, sample 1, RNA-seq
SAMC3554813	Wildtype, adult female Hatschek's pit, sample 2, RNA-seq
SAMC3554812	Wildtype, adult female Hatschek's pit, sample 1, RNA-seq
SAMC3554811	Wildtype, adult gill, sample 3, RNA-seq
SAMC3554810	Wildtype, adult gill, sample 2, RNA-seq
SAMC3554809	Wildtype, adult gill, sample 1, RNA-seq
SAMC3554808	Wildtype, adult ACV1 (forebrain), sample 4, RNA-seq
SAMC3554807	Wildtype, adult ACV1 (forebrain), sample 3, RNA-seq
SAMC3554806	Wildtype, adult ACV1 (forebrain), sample 2, RNA-seq
SAMC3554805	Wildtype, adult ACV1 (forebrain), sample 1, RNA-seq
SAMC3554804	Wildtype, adult midgut3 tissue, sample 3, RNA-seq
SAMC3554803	Wildtype, adult midgut3 tissue, sample 2, RNA-seq
SAMC3554802	Wildtype, adult midgut3 tissue, sample 1, RNA-seq
SAMC3554801	Wildtype, adult midgut2 tissue, sample 3, RNA-seq
SAMC3554800	Wildtype, adult midgut2 tissue, sample 2, RNA-seq
SAMC3554799	Wildtype, adult midgut2 tissue, sample 1, RNA-seq
SAMC3554798	Wildtype, adult midgut1 tissue, sample 3, RNA-seq
SAMC3554797	Wildtype, adult midgut1 tissue, sample 2, RNA-seq
SAMC3554796	Wildtype, adult midgut1 tissue, sample 1, RNA-seq
SAMC3554795	Wildtype, adult endostyle tissue, sample 3, RNA-seq
SAMC3554794	Wildtype, adult endostyle tissue, sample 2, RNA-seq
SAMC3554793	Wildtype, adult endostyle tissue, sample 1, RNA-seq
SAMC3554792	Ilp1 control, whole larvae, sample 5, RNA-seq
SAMC3554791	Ilp1 control, whole larvae, sample 4, RNA-seq
SAMC3554790	Ilp1 control, whole larvae, sample 3, RNA-seq
SAMC3554789	Ilp1 control, whole larvae, sample 2, RNA-seq
SAMC3554788	Ilp1 control, whole larvae, sample 1, RNA-seq
SAMC3554787	Ilp1 mutant, whole larvae, sample 5, RNA-seq
SAMC3554786	Ilp1 mutant, whole larvae, sample 4, RNA-seq
SAMC3554785	Ilp1 mutant, whole larvae, sample 3, RNA-seq
SAMC3554784	Ilp1 mutant, whole larvae, sample 2, RNA-seq
SAMC3554783	Ilp1 mutant, whole larvae, sample 1, RNA-seq
SAMC3554782	Pdx mutant, hepatic diverticulum, sample 2, RNA-seq
SAMC3554781	Pdx mutant, non-digestive tissue, sample 2, RNA-seq
SAMC3554780	Pdx control, midgut tissue, sample 2, RNA-seq
SAMC3554779	Pdx mutant, midgut tissue, sample 2, RNA-seq
SAMC3554778	Pdx control, non-digestive tissue, sample 2, RNA-seq
SAMC3554777	Pdx control, hepatic diverticulum, sample 2, RNA-seq
SAMC3554776	Pdx control, hepatic diverticulum, sample 1, RNA-seq
SAMC3554775	Pdx mutant, hepatic diverticulum, sample 1, RNA-seq
SAMC3554774	Pdx control, non-digestive tissue, sample 1, RNA-seq
SAMC3554773	Pdx mutant, midgut tissue, sample 1, RNA-seq
SAMC3554772	Pdx mutant, non-digestive tissue, sample 1, RNA-seq
SAMC3554771	Pdx control, midgut tissue, sample 1, RNA-seq
GSA (1)	-
CRA016137	Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates