| Accession |
PRJCA025886 |
| Title |
Dietary caloric restriction protects from Th17-cell pathogenicity in experimental autoimmune uveitis |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Mus musculus
|
| Description |
Uveitis, a central nervous system (CNS) autoimmune disease, is a common cause of blindness. Metabolic state and pathways profoundly influence Th cells fate and their functions. In addition, caloric restriction (CR) is known to ameliorate inflammatory and autoimmune diseases. However, careful characterization of the impact of CR on EAU is poorly understood. Here, single-cell RNA sequencing is performed to delineate the immune cell atlas of cervical draining lymph nodes (CDLNs) of both ad libitum (AL) and CR mice with or without EAU. |
| Sample scope |
Single cell |
| Release date |
2024-05-15 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
82122016
|
|
|
|
| Submitter |
Wenru
Su (suwr3@mail.sysu.edu.cn)
|
| Organization |
Zhongshan Ophthalmic Center,Sun Yat-sen University |
| Submission date |
2024-05-06 |
