| 项目编号 |
PRJCA026024 |
| 项目标题 |
Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in Pituitary neuroendocrine tumors |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Bone-invasive Pituitary Neuroendocrine Tumors (BI PitNETs) epitomize an aggressive subtype of pituitary tumors characterized by bone invasion, culminating in extensive bone destruction and fragmentation. This infiltration poses a significant surgical risk due to potential damage to vital nerves and arteries. However, the mechanisms underlying bone destruction caused by PitNETs remain elusive, and effective interventions for PitNET-induced bone destruction are lacking in clinical practice. In this study, we conducted single-cell transcriptomic and spatial transcriptomic profiling of BI PitNETs and Non-BI PitNETs samples to delineate differences in their immune microenvironments. Our study has identified a subset of macrophages with a higher proportion in the BI group, characterized by elevated expression of TNF-α. We named them TNF-α+ TAMs. TNF-α+ TAMs activate CD14+ monocytes by secreting TNF-α, driving their differentiation into osteoclasts and consequent bone destruction. Our study elucidates the critical role of TNF-α+ TAMs in PitNETs-induced bone destruction and highlights the intricate interplay between tumor cells and immune cells, laying a foundation for the development of preventive or therapeutic agents targeting pituitary tumor-induced bone destruction. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-05-10 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39865310
|
Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors
|
Journal of Experimental & Clinical Cancer Research
|
10.1186/s13046-025-03296-9
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82103028
|
|
|
|
| 提交者 |
Chuzhong
Li (lichuzhong@ccmu.edu.cn)
|
| 提交单位 |
Beijing Neurosurgical Institute |
| 提交日期 |
2024-05-10 |
