| 描述信息 |
The human cornea, a vital component of the visual system, undergoes age-related changes that impact ocular tissue function and susceptibility to disease. Despite its clinical significance, the cellular and molecular mechanisms underlying corneal aging remain incompletely understood. In this study, we present a high-resolution spatiotemporal transcriptomic and cell type atlas of human corneas obtained from male donors across different age groups. By integrating spatial transcriptomics (scStereo-seq) with single-cell RNA sequencing (scRNA-seq), we reveal age-related variability in gene expression, cellular composition, and spatial organization within major corneal cell types |
