| 项目编号 |
PRJCA026141 |
| 项目标题 |
Single-cell RNA and TCR sequencing data from cervical cancer patients before and after neoadjuvant immunotherapy |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Immunotherapy has garnered remarkable success in the treatment of cervical cancer patients. To further augment its effectiveness, it is crucial to elucidate the tumor microenvironment altered by this therapeutic approach. In this project, we gathered single-cell and TCR sequencing data from cervical cancer patients both prior to and following the administration of neoadjuvant immunotherapy. Our aim is to dissect the intricate cell subsets and the consequential microenvironmental shifts that are pivotal in determining the prognosis of immunotherapy. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-07-24 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40657372
|
Multi-Omics Analysis Reveals the transforming growth factor-β Signaling-Driven Multicellular Interactions with Prognostic Relevance in Cervical Cancer Progression
|
Journal of Cancer
|
10.7150/jca.114505
|
2025
|
| 41260902
|
Oligoclonal tumor-specific CD8 T-cell revival and IRE1α/XBP1-GDF15-mediated immunosuppressive niches determine neoadjuvant chemoimmunotherapy efficacy in cervical cancer
|
Journal for Immunotherapy of Cancer
|
10.1136/jitc-2025-012630
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2021YFC2701200
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82273091
|
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82203512
|
|
| Shanghai East Hospital
|
Clinical Research Foundation
|
DFLC2022029
|
|
|
|
| 提交者 |
Fang
Li (fang_li@tongji.edu.cn)
|
| 提交单位 |
Shanghai East Hospital |
| 提交日期 |
2024-05-13 |
