| 项目编号 |
PRJCA026519 |
| 项目标题 |
PDHA1 K83 succinylation modification in cholangiocarcinoma |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
Homo sapiens
|
| 描述信息 |
The incidence and mortality rates of cholangiocarcinoma have been on the rise, presenting challenges such as low detection rates, high mortality, and poor prognosis. There is a significantneed for in-depth research to improve clinical diagnosis and treatment. In our study, we explored a new mechanism of cholangiocarcinoma progression from the perspective of novel succinylation modifications. Our results indicate that succinylation of PDHA1 K83 alters PDH enzyme activity, leading to metabolic reprogramming of the TCA cycle. Thus, it is immportant to explore the mechanism of PDHA1 K83 succinylation. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-05-27 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40180922
|
Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation
|
Nature Communications
|
10.1038/s41467-025-58429-7
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
|
|
|
|
|
|
| 提交者 |
Lianxin
Liu (liulx@ustc.edu.cn)
|
| 提交单位 |
The First Affiliated Hospital of University of Science and Technology of China |
| 提交日期 |
2024-05-27 |
