| 项目编号 |
PRJCA026620 |
| 项目标题 |
Chip-Seq Data of H318LA and H4K12LA in Mouse Dorsal Root Ganglia (DRG) Following Sciatic Nerve Ligation-Induced Neuropathic Pain |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
|
| 物种名称 |
Mus
|
| 描述信息 |
this project is to investigate the epigenetic modifications in the dorsal root ganglia (DRG) of mice subjected to Spinal Nerve Ligation (SNL) compared to Sham-operated controls. Specifically, the study focuses on the histone modifications H3K18la and H4K12la, which are associated with chromatin structure and gene regulation. By performing Chromatin Immunoprecipitation sequencing (ChIP-seq) on DRG tissues 10 days post-surgery, we aim to identify changes in histone modifications that may underlie the molecular mechanisms of neuropathic pain. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-12-31 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neurons
|
Science Signaling
|
10.1126/scisignal.adr9397
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82371216
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81971054
|
|
|
|
| 提交者 |
BaoChun
Jiang (jiangbaochun@zju.edu.cn)
|
| 提交单位 |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2024-05-30 |
