| Accession | PRJCA026810 | ||||||||||||||||||||||||||||||||
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| Title | Dynamics of chromatin and transcriptome in the HSPCs at different hematopoietic developmental stages | ||||||||||||||||||||||||||||||||
| Relevance | Medicine and Biology | ||||||||||||||||||||||||||||||||
| Data types |
Whole genome sequencing
Epigenomics Transcriptome or Gene expression |
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| Organisms | Mus musculus | ||||||||||||||||||||||||||||||||
| Description | ATAC-seq and RNA-seq were used to compare the chromatin states and corresponding transcriptomes of developing HSPC. We found that the chromatin states and transcriptomes change markedly when HSPCs migrate from PL to FL and from FL to BM. Then we compared chromatin among E12.5 PL, E12.5 FL, and E16.5 FL, the proportion of fragments in the nucleosome-free region significantly increases in E12.5 and E16.5 FL-HSPCs compared with E12.5 PL-HSPCs; the motifs of ETS and Runt are enriched at the opeing or closing peaks from E12.5 PL to E12.5 FL and E12.5 FL to E16.5 FL, and the expression of these factors is either up-regulated or down-regulated; the motifs of bZIP and Zf are enriched at the closing and opening peaks from E12.5 PL to E12.5 FL and E12.5 FL to E16.5 FL respectively. In line, the expression of these factors is down-regulated or up-regulated. | ||||||||||||||||||||||||||||||||
| Sample scope | Monoisolate | ||||||||||||||||||||||||||||||||
| Release date | 2024-09-05 | ||||||||||||||||||||||||||||||||
| Publication |
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| Grants |
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| Submitter | Dengli Hong (dlhong@sjtu.edu.cn) | ||||||||||||||||||||||||||||||||
| Organization | Shanghai Jiaotong University School of Medicine | ||||||||||||||||||||||||||||||||
| Submission date | 2024-06-05 |