| Accession |
PRJCA026958 |
| Title |
Discovery of novel non-small-cell lung cancer genes in an alternative polyadenylation transcriptome-wide association study |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Alternative polyadenylation (APA) plays an essential role in cancer carcinogenesis and prognosis. However, the molecular characteristics of APA related to non-small cell lung cancer (NSCLC) susceptibility are understudied in East Asian populations. In this study, we constructed an atlas of APA-regulated 3'untranslated regions (3'UTR) profiles using RNA and matched DNA sequencing data from 417 Chinese NSCLC patients. We performed a 3'UTR APA transcriptome-wide association study (3'aTWAS) integrating genome-wide association studies in East Asians (7,035 cases and 185,413 controls) and identified three novel NSCLC-associated genes. In summary, we provided a road map for investigating the effects of genetic regulation in East Asian populations and demonstrated the substantial role of APA in NSCLC carcinogenesis and prognosis. |
| Sample scope |
Multiisolate |
| Release date |
2024-08-23 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province
|
|
2020E10004
|
|
| Healthy Zhejiang One Million People Cohort
|
|
K20230085
|
|
| Cancer Center, Zhejiang University and Key Research and Development Program of Zhejiang Province
|
|
2020C03002
|
|
|
|
| Submitter |
xifeng
Wu (xifengw@zju.edu.cn)
|
| Organization |
Zhejiang University School |
| Submission date |
2024-06-05 |
