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Accession PRJCA026987
Title CCL19-producing fibroblasts promote tertiary lymphoid structures formation augmenting anti-tumor IgG response in colorectal cancer liver metastasis
Relevance Medical
Data types Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
Organisms Homo sapiens
Description We provide a comprehensive comparative analysis of the immune ecosystems of CRLM with or without TLSs by spatial enhanced resolution omics-sequencing (Stereo-seq) (from 10 patients) and single cell RNA-sequencing (scRNA-seq) (from 14 patients). We disclose an important link between IgG+ PCs and TLSs, underlining the crucial role of IgG responses in anti-tumor immunity. We also find that fibroblast-derived CCL19 regulate B cell recruitment and TLSs formation, which can be a promising target to promote TLSs neogenesis and suppress CRLM growth.
Sample scope Multiisolate
Release date 2024-08-12
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) National Science Funds for Distinguished Young Scholars 81825013
Submitter Ming Kuang (kuangm@mail.sysu.edu.cn)
Organization The First Affiliated Hospital, Sun Yat-sen University
Submission date 2024-06-12

Project Data

Resource name Description
BioSample (10)  show -