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项目编号 PRJCA026987
项目标题 CCL19-producing fibroblasts promote tertiary lymphoid structures formation augmenting anti-tumor IgG response in colorectal cancer liver metastasis
涉及领域 Medical
数据类型 Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
物种名称 Homo sapiens
描述信息 We provide a comprehensive comparative analysis of the immune ecosystems of CRLM with or without TLSs by spatial enhanced resolution omics-sequencing (Stereo-seq) (from 10 patients) and single cell RNA-sequencing (scRNA-seq) (from 14 patients). We disclose an important link between IgG+ PCs and TLSs, underlining the crucial role of IgG responses in anti-tumor immunity. We also find that fibroblast-derived CCL19 regulate B cell recruitment and TLSs formation, which can be a promising target to promote TLSs neogenesis and suppress CRLM growth.
样品范围 Multiisolate
发布日期 2024-08-12
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) National Science Funds for Distinguished Young Scholars 81825013
提交者 Ming Kuang (kuangm@mail.sysu.edu.cn)
提交单位 The First Affiliated Hospital, Sun Yat-sen University
提交日期 2024-06-12

项目包含数据信息

资源名称 描述
BioSample (10)  show -