| 项目编号 |
PRJCA027271 |
| 项目标题 |
Deciphering the Pathogenesis of Male Penile Lichen Sclerosus through Multi-Omics Approaches |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Single cell sequencing
RNAseq and 16s rDNA
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This study aims to uncover the molecular mechanisms of male genital lichen sclerosus (LS) and its associated urethral cancer through multi-omics approaches. We will perform whole-genome sequencing, transcriptome sequencing, epigenome sequencing, proteomics, 16s rDNA sequencing and metabolomics on patients and control groups to comprehensively collect gene and protein expression data. By comparing functional differences in gene expression, we will identify significant differentially expressed genes and conduct functional annotation and pathway analysis to reveal the biological pathways involved. Further network analysis and experimental validation will help us understand the roles and mechanisms of these genes and pathways in LS and its associated urethral cancer, thereby providing a scientific basis for early diagnosis and personalized treatment of the disease. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-11-04 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Molecular Subtypes of Balanopreputial and Urethral Male Genital Lichen Sclerosus: Distinct Transcriptomic and Clinicopathological Profiles
|
Laboratory Investigation
|
10.1016/j.labinv.2025.104206
|
2025
|
| 40823862
|
Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus-induced urethral strictures
|
Microbiology Spectrum
|
10.1128/spectrum.00074-25
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81974085
|
|
| Science and Technology Commission of Shanghai Municipality
|
|
22S31901700
|
|
| International Cooperation Fund of the Science and Technology Commission of Shanghai Municipality
|
|
19410741700
|
|
| Science and Technology Commission of Shanghai Municipality
|
|
2022XD015
|
|
|
|
| 提交者 |
Lujie
Song (ljsong@sjtu.edu.cn)
|
| 提交单位 |
Shanghai Jiaotong University School of Medicine |
| 提交日期 |
2024-06-21 |
