| 项目编号 |
PRJCA027284 |
| 项目标题 |
Multi-omics study of solitary fibrous tumor of the central nervous system |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| 物种名称 |
|
| 描述信息 |
Solitary fibrosis tumor (SFT) is a rare tumor for which there are no effective treatment options. SFTs of the central system are particularly dangerous due to their anatomical location and recurrent nature. In the current study, we comprehensively characterized SFT and its primary cells using whole genome sequencing, RNA-seq, single cell RNAseq and single cell spatial RNAseq . We uncovered key mutations and signaling pathways in the tumor and small molecule drugs for tumor treatment. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-05-30 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40849425
|
Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors
|
Nature Communications
|
10.1038/s41467-025-63039-4
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2022YFA1103901
|
A study of the spatial and temporal evolutionary patterns of stem cell tumour formation
|
|
|
| 提交者 |
Jian
Chen (chenjian@cibr.ac.cn)
|
| 提交单位 |
Chinese Institute for Brain Research |
| 提交日期 |
2024-06-21 |
