| Accession |
PRJCA027471 |
| Title |
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ |
| Relevance |
Medical |
| Data types |
proteome
|
| Organisms |
Homo sapiens
|
| Description |
IR was ectopically expressed in HepG2 cells that were cultured in media without or with methyl-phenylalanine. Anti-FLAG M2 magnetic beads were employed to precipitate IR proteins.LC peaks eluted at the same time as those of standard synthetic peptides were subject to MS analysis with Orbitrap Fusion mass spectrometer. |
| Sample scope |
Monoisolate |
| Release date |
2024-06-29 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ
|
Nature communications
|
10.1038/s41467-022-32000-0
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0800300
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0801300
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31821002
|
|
|
|
| Submitter |
Zhiling
Zhang (zlzhang12@fudan.edu.cn)
|
| Organization |
Fudan University |
| Submission date |
2024-06-27 |
