| Accession |
PRJCA027542 |
| Title |
Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation |
| Relevance |
Metabolism |
| Data types |
Transcriptome or Gene expression
LC-MS data
|
| Organisms |
Homo sapiens
|
| Description |
Global histone acetylation varies with changes in the nutrient and cell cycle phases; however, the mechanisms connecting these variations are not fully understood. Herein, we report that nutrient-related and cell-cycle-regulated nuclear acetate regulates global histone acetylation. Histone deacetylation-generated acetate accumulates in the nucleus and induces histone hyperacetylation. The nuclear acetate levels were controlled by glycolytic enzyme triosephosphate isomerase 1 (TPI1). Cyclin-dependent kinase 2 (CDK2), which is phosphorylated and activated by nutrient-activated mTORC1, phosphorylates TPI1 Ser 117 and promotes nuclear translocation of TPI1, decreases nuclear dihydroxyacetone phosphate (DHAP) and induces nuclear acetate accumulation because DHAP scavenges acetate via the formation of 1-acetyl-DHAP. CDK2 accumulates in the cytosol during the late G1/S phases. Inactivation or blockade of nuclear translocation of TPI1 abrogates nutrient-dependent and cell-cycle-dependent global histone acetylation, chromatin condensation, gene transcription and DNA replication. These results identify the mechanism of maintaining global histone acetylation by nutrient and cell cycle signals. |
| Sample scope |
Monoisolate |
| Release date |
2024-06-29 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34140692
|
|
|
|
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0800300
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0801300
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31821002
|
|
|
|
| Submitter |
Jiaojiao
Zhang (17110700011@fudan.edu.cn)
|
| Organization |
Fudan University |
| Submission date |
2024-06-29 |
