| 项目编号 |
PRJCA027702 |
| 项目标题 |
Reversing Immunosenescence with Senolytics to Enhance Tumor Immunotherapy |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Recent advancements in cancer immunotherapy have significantly improved patient outcomes, yet responses remain moderate. In a phase II clinical trial (OOC 001, NCT04718415) involving 51 cancer patients, we conducted singlecell RNA and TCR or BCR sequencing on tumor and blood samples. Our findings associate poor immunotherapy response with reduced levels of CCR7+ CD4 Naive T cells and CD27+ Memory B cells, as well as higher expression of immunosenescence-related genes in T and B cell subsets of non-responders. Importantly, studies using syngeneic mouse models and an Ercc1+/- aging mouse model, along with ongoing trials (COIS-01, NCT05724329), validate that senolytics enhance the therapeutic efficacy of immunotherapy in multiple solid tumors by mitigating tumor immunosenescence. These results underscore the critical role of immunosenescence and its senescent features in the tumor microenvironment on immunotherapy outcomes, suggesting that modulation could enhance cancer immunotherapy efficacy. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-04-24 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Sun Yat-sen University
|
Fundamental Research Funds for the Central Universities
|
16ykpy10
|
|
| Sun Yat-sen University
|
Fundamental Research Funds for the Central Universities
|
19ykzd20
|
|
| National Natural Science Foundation of China (NSFC)
|
The Joint Funds
|
U21A20381
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82373452
|
|
| Guangdong Natural Science Funds
|
Distinguished Young Scholar
|
2022B1515020061
|
|
| Guangzhou Basic Research Program Jointly Funded by Municipal Schools (Institutes)
|
|
202201020367
|
|
| Guangdong Basic and Applied Basic Research Foundation
|
|
2021A1515220138
|
|
|
|
| 提交者 |
Song
Fan (fansong2@mail.sysu.edu.cn)
|
| 提交单位 |
Sun Yat-sen Memorial Hospital, Sun Yat-sen University |
| 提交日期 |
2024-07-03 |
