| 项目编号 | PRJCA027720 | ||||||||||||||||||||
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| 项目标题 | Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution | ||||||||||||||||||||
| 涉及领域 | Evolution | ||||||||||||||||||||
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads Single cell sequencing |
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| 物种名称 | Eudontomyzon morii | ||||||||||||||||||||
| 描述信息 | Lymphocyte receptors independently evolved in both jawed and jawless vertebrates with similar adaptive immune responses. However, the diversity of functional subtypes and molecular architecture in jawless vertebrate lymphocytes, comparable to jawed species, is not well defined. Here, we profile the gills, intestines, and blood of the lamprey, Lampetra morii, with single-cell RNA sequencing, using a full-length transcriptome as a reference. Our findings reveal higher tissue-specific heterogeneity among T-like cells in contrast to B-like cells. Notably, we identify a unique T-like cell subtype expressing a homolog of the nonlymphoid hematopoietic growth factor receptor, MPL like (MPL-L). These MPL-L+ T-like cells exhibit features distinct from T cells of jawed vertebrates, particularly in their elevated expression of hematopoietic genes. We further discovered that MPL-L+ VLRA+ T-like cells are widely present in the typhlosole, gill, liver, kidney, and skin of lamprey and they proliferate in response to both a T cell mitogen and recombinant human thrombopoietin. These findings provide new insights into the adaptive immune response in jawless vertebrates, shedding new light on the evolution of adaptive immunity. | ||||||||||||||||||||
| 样品范围 | Single cell | ||||||||||||||||||||
| 发布日期 | 2024-07-04 | ||||||||||||||||||||
| 项目资金来源 |
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| 提交者 | Yingyi Huang (1074163132@qq.com) | ||||||||||||||||||||
| 提交单位 | Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences | ||||||||||||||||||||
| 提交日期 | 2024-07-04 |