Accession PRJCA027770
Title DNA methylation safeguards generation of hematopoietic stem and progenitor cell by repression of Notch signaling
Relevance Evolution
Data types Epigenomics
Transcriptome or Gene expression
Organisms Danio rerio
Description we used multi-omics approaches together with functional assays to assess global DNA methylome dynamics during the endothelial cells to HSPCs transition in zebrafish, and determined that DNA methyltransferase 1 (Dnmt1) is essential for HSPC generation via repression of Notch signaling.
Sample scope Synthetic
Release date 2024-07-12
PubMed ID Article title Journal name DOI Year
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2018YFA0801200
Accessions in other database
Accession Database name
GSE189072 NCBI
Submitter Lu    Wang  (
Organization Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences
Submission date 2024-07-04

Project Data

Resource name Description
BioSample (34)  show -
GSA (2) -
CRA017640 RNA-seq data of HSPC
CRA017626 DNA methylation data of HSPC