| 项目编号 | PRJCA027770 | ||||||||||
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| 项目标题 | DNA methylation safeguards generation of hematopoietic stem and progenitor cell by repression of Notch signaling | ||||||||||
| 涉及领域 | Evolution | ||||||||||
| 数据类型 |
Epigenomics
Transcriptome or Gene expression |
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| 物种名称 | Danio rerio | ||||||||||
| 描述信息 | we used multi-omics approaches together with functional assays to assess global DNA methylome dynamics during the endothelial cells to HSPCs transition in zebrafish, and determined that DNA methyltransferase 1 (Dnmt1) is essential for HSPC generation via repression of Notch signaling. | ||||||||||
| 样品范围 | Synthetic | ||||||||||
| 发布日期 | 2024-07-12 | ||||||||||
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| 提交者 | Lu Wang (wanglu1@ihcams.ac.cn) | ||||||||||
| 提交单位 | Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences | ||||||||||
| 提交日期 | 2024-07-04 |