| Accession | PRJCA027770 | ||||||||||
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| Title | DNA methylation safeguards generation of hematopoietic stem and progenitor cell by repression of Notch signaling | ||||||||||
| Relevance | Evolution | ||||||||||
| Data types |
Epigenomics
Transcriptome or Gene expression |
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| Organisms | Danio rerio | ||||||||||
| Description | we used multi-omics approaches together with functional assays to assess global DNA methylome dynamics during the endothelial cells to HSPCs transition in zebrafish, and determined that DNA methyltransferase 1 (Dnmt1) is essential for HSPC generation via repression of Notch signaling. | ||||||||||
| Sample scope | Synthetic | ||||||||||
| Release date | 2024-07-12 | ||||||||||
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| Submitter | Lu Wang (wanglu1@ihcams.ac.cn) | ||||||||||
| Organization | Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences | ||||||||||
| Submission date | 2024-07-04 |