| Accession |
PRJCA027915 |
| Title |
Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
This study explores the structural components of the thymus and their role in T cell development using advanced techniques such as single-cell transcriptomics, VDJ sequencing, spatial transcriptomics. By developing the TSO-his algorithm, diverse datasets were integrated to map the thymus's architecture, pinpointing critical regions, cell types, stages of T cell maturation, and markers. The study confirmed known roles of cells and genes in T cell development, uncovered novel T cell types and genetic factors, and highlighted ELOVL4's regulatory role in CD4+ T cell maturation. These findings enhance the understanding of thymic biology and potential therapeutic targets for T cell-related immune responses. |
| Sample scope |
Single cell |
| Release date |
2024-07-19 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
3230080508
|
|
| Nanjing Medical University Launches Research Initiation Fund for Talent Recruitment
|
|
NMUR20230007
|
|
| Jiangsu Funding Program for Excellent Postdoctoral Talent
|
|
2022ZB699
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82173378
|
|
| National High Level Hospital Clinical Research Funding
|
|
2023-NHLHCRF-DJMS-06
|
|
|
|
| Submitter |
Shiping
Jiao (jiaoshp@mail2.sysu.edu.cn)
|
| Organization |
Nanjing Drum Tower Hospital |
| Submission date |
2024-07-10 |
