| Accession |
PRJCA028123 |
| Title |
Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension |
| Relevance |
Medical |
| Data types |
metalobome
|
| Organisms |
Homo sapiens
|
| Description |
We found that ME1 protein level and enzymatic activity were highly elevated in lung tissues of patients and mice with PH, primarily in vascular endothelial cells. Global knockout of ME1 protected mice from developing hypoxia- or SuHx-induced PH. Endothelial-speciffc ME1 deletion similarly attenuated pulmonary vascular remodeling and PH development in mice, suggesting a critical role of endothelial ME1 in PH. |
| Sample scope |
Monoisolate |
| Release date |
2024-07-16 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension
|
circulation
|
10.1161/CIRCULATIONAHA.123.067579
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Key Research and Development Program of China
|
|
2022YFA0806302
|
|
|
|
| Submitter |
wei
li (942013819@qq.com)
|
| Organization |
Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College |
| Submission date |
2024-07-16 |
