| 项目编号 |
PRJCA028293 |
| 项目标题 |
Single-cell transcriptome in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy sequencial with PD-1 inhibitor |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Radiotherapy is the first-line treatment for locally advanced cervical squamous cell cancer (CSCC), however, approximately 50% of patients progressed after radical radiotherapy and the molecular mechanisms are unclear. Thus, understanding of the role of concurrent chemoradiotherapy sequential PD-1 inhibitor and the molecular responses of different cell types in tumor exposed to radiotherapy or ICI is pivotal for improving the efficiency or causing the side effects in CSCC treatment. Here, we performed multi-omics, such as single-cell RNA-seq, bulk RNAseq and TCR/BCR sequencing et al to construct high-resolution molecular landscape of various cell types in CSCC before and during radiotherapy and ICI. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-10-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39903771
|
Radiotherapy‐Associated Cellular Senescence and EMT Alterations Contribute to Distinct Disease Relapse Patterns in Locally Advanced Cervical Cancer
|
Advanced Science
|
10.1002/advs.202412574
|
2025
|
| 41430079
|
Distinct immune cell dynamics associated with immune-related adverse events during combined chemoradiation and immune checkpoint inhibitor therapy
|
Nature Communications
|
10.1038/s41467-025-67689-2
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82272747
|
|
|
|
| 提交者 |
Lei
Zhang (hrbmuzl@126.com)
|
| 提交单位 |
Renji Hospital, School of Medicine, Shanghai Jiao Tong University |
| 提交日期 |
2024-07-19 |
