| 项目编号 |
PRJCA028331 |
| 项目标题 |
N-acetyltransferase 10 is implicated in the pathogenesis of cycling T cell-mediated autoimmune and inflammatory disorders |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
The process of T cell expansion, including cycling T cells, plays a crucial role in both autoimmune and chronic inflammatory diseases. However, the precise regulatory mechanisms governing the process of T cell expansion, particularly the cycling T cell population, remain poorly understood. In this study, we reveal that the deficiency of NAT10 expressed in T cells, exhibit a notable decrease in mature T cell numbers in peripheral lymphoid organs. NAT10 contributes to the regulation of T cell activation and proliferation upon antigen stimulation. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-07-20 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40615576
|
NAT10-mediated acetylation of NIK mRNA in B cells promotes IgA production
|
EMBO Reports
|
10.1038/s44319-025-00509-2
|
2025
|
| 39477944
|
N-acetyltransferase 10 is implicated in the pathogenesis of cycling T cell-mediated autoimmune and inflammatory disorders in mice
|
Nature Communications
|
10.1038/s41467-024-53350-x
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
National Science Funds for Distinguished Young Scholars
|
82125016
|
|
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
82230061
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2018YFD0500100
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82301968/82202019
|
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82202019
|
|
|
|
| 提交者 |
Wenping
Li (tico332624@email.swu.edu.cn)
|
| 提交单位 |
The Third Affiliated Hospital, Sun Yat-Sen University |
| 提交日期 |
2024-07-20 |
