| 项目编号 | PRJCA028360 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 项目标题 | S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting fatty acid metabolism | ||||||||||||
| 涉及领域 | Medical | ||||||||||||
| 数据类型 |
Transcriptome or Gene expression
Single cell sequencing |
||||||||||||
| 物种名称 |
Mus musculus
Homo sapiens |
||||||||||||
| 描述信息 | Lung cancer is preceded by premalignant lesions, and what factors drive this transformation and the potential regulatory mode in the context of tumor initiation remain to be elucidated. In the course of precancerous lesions, we found a phasic shift in metabolic patterns. Macrophages are a heterogeneous cell population with high plasticity in the tumor microenvironment. Single-cell interaction and metabolic analyses highlighted a cellular state, S100a4+ alveolar macrophages, which exhibited distinct fatty acid metabolic activity, such as palmitic acid metabolism, at the atypical adenomatous hyperplasia stage, accompanied by an angiogenic promoting function in a pre-neoplastic setting. These findings were reproducible in human single-cell transcriptome and had been confirmed by histopathological staining and in vitro cell coculture assays. Taken together, the results from this study demonstrated that specific alveolar macrophage subset contributes to tumorigenesis by altering its metabolic state, suggesting that metabolic interventions targeting this cell state in the early stage of disease may delay neoplastic transformation of the lung epithelium. | ||||||||||||
| 样品范围 | Single cell | ||||||||||||
| 发布日期 | 2025-05-28 | ||||||||||||
| 项目资金来源 |
|
||||||||||||
| 提交者 | Li Zhang (zhangli7375@scu.edu.cn) | ||||||||||||
| 提交单位 | West China Hospital, Sichuan University | ||||||||||||
| 提交日期 | 2024-07-22 |