项目编号

PRJCA028360

项目标题

S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting fatty acid metabolism

涉及领域

Medical

数据类型

Transcriptome or Gene expression
Single cell sequencing

物种名称

Mus musculus
Homo sapiens

描述信息

Lung cancer is preceded by premalignant lesions, and what factors drive this transformation and the potential regulatory mode in the context of tumor initiation remain to be elucidated. In the course of precancerous lesions, we found a phasic shift in metabolic patterns. Macrophages are a heterogeneous cell population with high plasticity in the tumor microenvironment. Single-cell interaction and metabolic analyses highlighted a cellular state, S100a4+ alveolar macrophages, which exhibited distinct fatty acid metabolic activity, such as palmitic acid metabolism, at the atypical adenomatous hyperplasia stage, accompanied by an angiogenic promoting function in a pre-neoplastic setting. These findings were reproducible in human single-cell transcriptome and had been confirmed by histopathological staining and in vitro cell coculture assays. Taken together, the results from this study demonstrated that specific alveolar macrophage subset contributes to tumorigenesis by altering its metabolic state, suggesting that metabolic interventions targeting this cell state in the early stage of disease may delay neoplastic transformation of the lung epithelium.

样品范围

Single cell

发布日期

2025-05-28

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
40658605	S100a4 + alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism eLife Assessment Reviewer #1 (Public review): Reviewer #2 (Public review): Author response	eLife	10.7554/eLife.101731	2025

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
National Natural Science Foundation of China (NSFC)		92159302
National Natural Science Foundation of China (NSFC)		62372316

提交者

Li Zhang (zhangli7375@scu.edu.cn)

提交单位

West China Hospital, Sichuan University

提交日期

2024-07-22

项目包含数据信息

资源名称	描述
BioSample (19) show	-
SAMC4035626	scRNA-seq of mus musculus: adult male lung
SAMC4035625	scRNA-seq of mus musculus: adult female lung
SAMC4035624	scRNA-seq of mus musculus: adult male lung
SAMC4035623	scRNA-seq of mus musculus: adult male lung
SAMC4035622	scRNA-seq of mus musculus: adult male lung
SAMC4035621	scRNA-seq of mus musculus: adult female lung
SAMC4035620	scRNA-seq of mus musculus: adult male lung
SAMC4035619	scRNA-seq of mus musculus: adult female lung
SAMC4035618	scRNA-seq of mus musculus: adult male lung
SAMC4035617	scRNA-seq of mus musculus: adult male lung
SAMC4035616	scRNA-seq of mus musculus: adult male lung
SAMC4035615	scRNA-seq of mus musculus: adult female lung
SAMC4035614	scRNA-seq of mus musculus: adult male lung
SAMC4035613	scRNA-seq of mus musculus: adult female lung
SAMC4035612	scRNA-seq of mus musculus: adult male lung
SAMC4035611	scRNA-seq of mus musculus: adult female lung
SAMC4035610	scRNA-seq of mus musculus: adult female lung
SAMC4035609	scRNA-seq of mus musculus: adult female lung
SAMC4035608	scRNA-seq of mus musculus: adult male lung
GSA (1)	-
CRA025954	S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism