| 项目编号 |
PRJCA028825 |
| 项目标题 |
CAR-T cells eradicating CD19+/BCMA+ autoantibody-producing clones for SLE treatment |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
CD19 and BCMA CAR-T cells are safe for the treatment of SLE patients and can achieve immune reset through deep and comprehensive clearance of pathogenic antibody-secreting cells, resulting in sustained drug-free remission. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-07-25 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40993243
|
Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial
|
Nature Medicine
|
10.1038/s41591-025-03937-8
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82130003
|
|
|
|
| 提交者 |
He
Huang (huanghe@zju.edu.cn)
|
| 提交单位 |
The First Affiliated Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2024-07-31 |
