| Accession |
PRJCA028825 |
| Title |
CAR-T cells eradicating CD19+/BCMA+ autoantibody-producing clones for SLE treatment |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
CD19 and BCMA CAR-T cells are safe for the treatment of SLE patients and can achieve immune reset through deep and comprehensive clearance of pathogenic antibody-secreting cells, resulting in sustained drug-free remission. |
| Sample scope |
Single cell |
| Release date |
2025-07-25 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 40993243
|
Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial
|
Nature Medicine
|
10.1038/s41591-025-03937-8
|
2025
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82130003
|
|
|
|
| Submitter |
He
Huang (huanghe@zju.edu.cn)
|
| Organization |
The First Affiliated Hospital, Zhejiang University School of Medicine |
| Submission date |
2024-07-31 |
