| Description |
Here, we found that the intratumoral bacteria Brevibacillus parabrevis (B. parabrevis) inhibited NK cell ferroptosis by promoting lipolysis into acetyl-CoA. Mechanistically, B. parabrevis catalyzed the acetylation of RORC, enhancing its binding to the NEDD4L promoter. NEDD4L induced ubiquitination of iron transporters SLC39A14, SLC39A8, and STEAP3. Functionally, B. parabrevis induced NK cells to differentiate into adaptability, cytotoxicity, and heat shock, inhibiting the terminal phenotype and changing the tumor microenvironment from cold to hot. |
