| 项目编号 |
PRJCA029040 |
| 项目标题 |
Intratumoral bacteria Brevibacillus parabrevis in hepatocellular carcinoma enhances antitumor immunity by inhibiting NK cell ferroptosis_CyTOF |
| 涉及领域 |
Medical |
| 数据类型 |
Mass cytometry
|
| 物种名称 |
Mus musculus
Homo sapiens
|
| 描述信息 |
Here, we found that the intratumoral bacteria Brevibacillus parabrevis (B. parabrevis) inhibited NK cell ferroptosis by promoting lipolysis into acetyl-CoA. Mechanistically, B. parabrevis catalyzed the acetylation of RORC, enhancing its binding to the NEDD4L promoter. NEDD4L induced ubiquitination of iron transporters SLC39A14, SLC39A8, and STEAP3. Functionally, B. parabrevis induced NK cells to differentiate into adaptability, cytotoxicity, and heat shock, inhibiting the terminal phenotype and changing the tumor microenvironment from cold to hot. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-08-22 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40399270
|
Intratumoral Brevibacillus parabrevis enhances antitumor immunity by inhibiting NK cell ferroptosis in hepatocellular carcinoma
|
Cell Death & Disease
|
10.1038/s41419-025-07733-7
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82372936
|
|
|
|
| 提交者 |
Banglun
Pan (1335563838@qq.com)
|
| 提交单位 |
Fujian Medical University Union Hospital |
| 提交日期 |
2024-08-12 |
