| 项目编号 |
PRJCA029367 |
| 项目标题 |
Parallel Single-Cell/Nucleus and Spatial Transcriptome Analyses Reveal Intra- and Peri-Neural Microenvironment in PDAC |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This study aims to explore the role of nerves in tumor biology, particularly focusing on their function and the impact of the neural microenvironment in cancer invasion. Utilizing multi-omics technologies, we have mapped the spatial transcriptomic landscape of nerve-associated cells in pancreatic ductal adenocarcinoma (PDAC). By analyzing tissue samples with varying degrees of neural invasion, we have uncovered the complex interactions between tumor cells, immune cells, and neurons, providing new insights into the mechanisms underlying nerve-tumor interactions. This research lays the groundwork for future studies in cancer neuroscience and potentially advances the development of novel therapeutic strategies. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-10-14 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Shenzhen Bay Laboratory,SZBL
|
|
S201101004-2
|
|
|
|
| 提交者 |
Minmin
Chen (chenmm@szbl.ac.cn)
|
| 提交单位 |
Shenzhen Bay Laboratory |
| 提交日期 |
2024-08-22 |
