| 项目编号 |
PRJCA029474 |
| 项目标题 |
Single-cell and Spatial transcriptomic atlas of gallbladder cancer liver invasion |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
Spatial transcriptomic sequencing
|
| 物种名称 |
|
| 描述信息 |
The poor survival rate of gallbladder cancer (GBC), coupled with the aggressive nature of liver invasion, underscores the urgency of understanding the underlying mechanisms. Our study addresses this gap by dissecting the complex cellular interactions and spatial architecture at the tumor-liver interface with single-cell and spatial transcriptomics. In this study, we comprehensively profiled 40 10X Visium spatial slides and 27 single-cell transcriptome data for multiple sampling sites from 8 patients, enabling systematical depicting of the microenvironment of liver-invading gallbladder cancer. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-12-24 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41766656
|
Macrophage-rich niches regulate T cell dynamics at the liver invasive margin during gallbladder cancer progression
|
The Journal of Clinical Investigation
|
10.1172/JCI193672
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
32130036
|
|
| Shanghai Shenkang Clinical Technology Innovation Project
|
|
SHDC12021101
|
|
| Basic Research Project of Science and Technology Commission of Shanghai Municipality
|
|
20JC1419100
|
|
|
|
| 提交者 |
Yingbin
Liu (721006819@shsmu.edu.cn)
|
| 提交单位 |
Renji Hospital, School of Medicine, Shanghai Jiao Tong University |
| 提交日期 |
2024-08-26 |
