| Accession |
PRJCA029523 |
| Title |
The role and mechanisms of cell-cell junction in the pathogenesis of hidradenitis suppurativa/acne inversa |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Acne inversa (AI) is a occlusion disease of hair follicular caused by both genetic and environmental factors such as cigarette smoking. We have found the AI patients had cell-cell junctions gene mutations, and claudin-1 expression was decreased in sebaceous glands of AI skin detected by IHC. We hypothesize that claudins mutation is probably the genetic background of AI and the decline of claudin-1 expression attenuated its inhibition of AhR/Wnt/b-catenin pathway activated by smoking. This study aims to clarify the correlation between cell-cell junction gene mutations and AI phenotypes, and explore the regulation of claudin-1 on AhR/Wnt/b-catenin pathway and its induction to sebaceous gland differentiation, follicular occluding and cyst formation and so on pathogenesis in AI, so as to provide new ideas for unveiling the multifactorial pathogenesis of AI. |
| Sample scope |
Multiisolate |
| Release date |
2024-09-26 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82373506
|
The role and mechanisms of Claudin-1 in regulating sebocytes differentiation via AhR/Wnt/b-Catenin signaling pathway in acne inversa
|
|
|
| Submitter |
Qiang
Ju (qiangju@aliyun.com)
|
| Organization |
Renji Hospital, School of Medicine, Shanghai Jiao Tong University |
| Submission date |
2024-08-27 |
