| 项目编号 |
PRJCA029849 |
| 项目标题 |
Circulating Tumor DNA for Molecular Residual Disease Detection in Epithelial Ovarian Cancer |
| 涉及领域 |
Medical |
| 数据类型 |
Targeted Locus (Loci)
Variation
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This project investigates the use of circulating tumor DNA (ctDNA) for the detection of molecular residual disease (MRD) in patients with epithelial ovarian cancer (EOC) who have undergone primary debulking surgery and adjuvant chemotherapy. Despite standard treatments, EOC patients often face relapse, highlighting the need for effective post-treatment monitoring. By analyzing ctDNA in plasma samples collected before and after treatment, alongside tumor tissue sequencing, we aim to identify tumor-specific genetic variants that could serve as early warning signs for potential relapse. This approach has the potential to improve post-operative surveillance and contribute to more personalized treatment strategies for EOC patients. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-09-04 |
| 出版信息 |
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National High Level Hospital Clinical Research Funding
|
|
2022-PUMCH-B-083
|
|
| Capital's Funds for Health Improvement and Research
|
|
2022-1-4011
|
|
|
|
| 提交者 |
Yang
Xiang (xiangy@pumch.cn)
|
| 提交单位 |
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College |
| 提交日期 |
2024-09-04 |
